Physical Phenotyping
Prof. Dino Di Carlo, UCLA
February 17, 2015 3:00 pm (Food starting at 2:30 pm)
Blum Hall room 330
Physical properties of cells can provide integrative, rapid, and low-cost information about disease. I will discuss a range of microtechnologies that assay the physical properties of cells in a high-throughput and quantitative manner for applications in diagnostics and drug screening. Amongst the host of physical properties (the cellular physome) we have initially focused on the development of instruments that measure single-cell properties associated with metastasis and invasion, immune activation, and cell differentiation state. These include deformability, size, morphology, motility, adhesiveness, and contractility. In this talk I will introduce high-throughput and quantitative approaches addressing three of these areas – deformability cytometry, force phenotyping, and vortex trapping. These tools are achieving the promise of cost-effective and rapid sample preparation, diagnosis and screening for assaying immune cell function, tumor cell malignancy, and other cell fate decisions.
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Dino Di Carlo is an Associate Professor in the Department of Bioengineering at the University of California, Los Angeles where he directs the Microfluidic Biotechnology Laboratory. He is also a member of the California NanoSystems Institute (CNSI), and Jonsson Comprehensive Cancer Center – Cancer Nanotechnology Program Area. He received his B.S. in Bioengineering from the University of California, Berkeley in 2002 and received a Ph.D. in Bioengineering from the University of California, Berkeley and San Francisco in 2006 in Luke Lee’s BioPOETS Lab. He then conducted postdoctoral studies from 2006-2008 at the Center for Engineering in Medicine at Harvard Medical School and Massachusetts General Hospital under the guidance of Mehmet Toner. His research focuses on exploiting unique physics, microenvironment control, and the potential for automation associated with miniaturized systems for applications in basic biology, medical diagnostics, and cellular engineering. He is actively involved in technology entrepreneurship, serving as a co-founder of CytoVale, Vortex Biosciences, and Tempo Therapeutics. Among other honors he was recently awarded the Analytical Chemistry Young Innovator Award in 2014, the National Science Foundation (NSF) Early CAREER Award and U.S. Office of Naval Research (ONR) Young Investigator Award in 2012, a Packard Fellowship and Defense Advanced Research Projects Agency (DARPA) Young Faculty Award in 2011, and the National Institutes of Health (NIH) Director’s New Innovator Award and Coulter Translational Research Award in 2010.
Prof. Dino Di Carlo, UCLA
February 17, 2015 3:00 pm (Food starting at 2:30 pm)
Blum Hall room 330
Physical properties of cells can provide integrative, rapid, and low-cost information about disease. I will discuss a range of microtechnologies that assay the physical properties of cells in a high-throughput and quantitative manner for applications in diagnostics and drug screening. Amongst the host of physical properties (the cellular physome) we have initially focused on the development of instruments that measure single-cell properties associated with metastasis and invasion, immune activation, and cell differentiation state. These include deformability, size, morphology, motility, adhesiveness, and contractility. In this talk I will introduce high-throughput and quantitative approaches addressing three of these areas – deformability cytometry, force phenotyping, and vortex trapping. These tools are achieving the promise of cost-effective and rapid sample preparation, diagnosis and screening for assaying immune cell function, tumor cell malignancy, and other cell fate decisions.
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Dino Di Carlo is an Associate Professor in the Department of Bioengineering at the University of California, Los Angeles where he directs the Microfluidic Biotechnology Laboratory. He is also a member of the California NanoSystems Institute (CNSI), and Jonsson Comprehensive Cancer Center – Cancer Nanotechnology Program Area. He received his B.S. in Bioengineering from the University of California, Berkeley in 2002 and received a Ph.D. in Bioengineering from the University of California, Berkeley and San Francisco in 2006 in Luke Lee’s BioPOETS Lab. He then conducted postdoctoral studies from 2006-2008 at the Center for Engineering in Medicine at Harvard Medical School and Massachusetts General Hospital under the guidance of Mehmet Toner. His research focuses on exploiting unique physics, microenvironment control, and the potential for automation associated with miniaturized systems for applications in basic biology, medical diagnostics, and cellular engineering. He is actively involved in technology entrepreneurship, serving as a co-founder of CytoVale, Vortex Biosciences, and Tempo Therapeutics. Among other honors he was recently awarded the Analytical Chemistry Young Innovator Award in 2014, the National Science Foundation (NSF) Early CAREER Award and U.S. Office of Naval Research (ONR) Young Investigator Award in 2012, a Packard Fellowship and Defense Advanced Research Projects Agency (DARPA) Young Faculty Award in 2011, and the National Institutes of Health (NIH) Director’s New Innovator Award and Coulter Translational Research Award in 2010.
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